| 2010 South Carolina NFL District |
| Code | School | Coach | |
|---|---|---|---|
| SA | Mauldin High School | Alison Flowers | |
| SB | Hillcrest High School | Bill Evans | |
| SC | Academic Magnet High School | Frank Flanigan | |
| SD | Christ Church Episcopal School | Donna Miller | |
| SE | Southside Center for Intl Studies | Erickson Bynum | |
| SF | Bob Jones Academy | Chuck Nicholas | |
| SG | Riverside High School | Greg Cook |